Enfamil vs Similac | Which is Best for Your Baby?

If you’re a new mom, or currently expecting a baby, there will be countless decisions to make about every aspect of your child’s life. One of the most important is what you will feed them during their infancy. If you decide that formula is the best option for your family, there are plenty of fantastic products to try. A lot of moms find that it’s a straight choice between two of the leading brands – Enfamil vs Similac.

In this article, we’ll explore the features, benefits, and disadvantages of each brand, to help you make an informed decision.

What to Look for in an Infant Milk

All infant milks have been developed to give your baby a complete nutritional profile, appropriate to their age. You’ll find that infant milks are available in different age categories; this is because the quantities of nutrients that your baby needs will adjust over time.

Most infant formulas use cow’s milk as a base. There may be reasons why regular cow’s milk formulas don’t work, for example, if your baby has a lactose intolerance. Fortunately, there are lots of alternatives that have lactose reduced or removed, soy-based milks, or amino-acid formulas for children who have allergies to both milk and soy. Your pediatrician will be able to suggest a specialist formula if your child has difficulty with mainstream options.

Looking at Enfamil vs Similac, both brands offer standard milks, as well as a range formulas that cater to preemies, babies with allergies and tummy upsets, and soy alternatives.

Enfamil Overview 


Enfamil is an incredibly popular infant formula brand. They have a wide range of products, including:

  • Enfamil Infant – a standard formula for children from newborn to 1 year.
  • Enfamil Premium Newborn – a formula designed to replicate the nutritional profile of breastmilk for the youngest babies.
  • Enfamil Gentlease – a formula for babies who experience gastro symptoms, such as excess gas or trouble winding.
  • Enfamil Nutramigen – a hypoallergenic formula for infants who suffer from milk allergies.
  • Enfamil ProSobee – a soy-based formula for babies who cannot tolerate cow’s milk, or for those who will be fed a plant-based diet.


When considering Enfamil vs Similac, what we’ve found with both brands is that the product range is extensive. Enfamil carries formulas for all types of baby; from newborns, to children with allergies, to those whose parents decide that a plant-based diet is best.

All products come in powder form, but many are also available in convenient pre-mixed bottles. This is great for parents on the move, who may not have the right amount of powder with them, or simply prefer the convenience of a pre-mixed formula when out and about.


It’s worth checking the ingredients list before you purchase a pack of Enfamil. Some parents may choose not to feed their babies corn syrup, for example, and this is present in the majority of Enfamil formulas. Similarly, if you’re avoiding GMOs, it’s worth noting that several of Enfamils’s products contain this. This, of course, is a matter of preference that may guide your Enfamil vs Similac decision.

Similac Overview


Just like Enfamil, Similac offers a wide range of products for all types of baby and dietary requirement. A selection includes:

  • Similac Organic – a standard formula with organic ingredients.
  • SimilacNeoSure – a formula prepared for premature babies.
  • Similac Pro-Total Comfort – a gentle formula to ease gastro symptoms in babies.
  • Similac Sensitive – for babies with milk allergies.
  • Similac Soy Isomil – a soy-based formula for babies with milk allergies and those fed a plant-based diet.


The Similac range has plenty of options for babies with allergies, tummy upsets, and gas problems. We also appreciate that there’s a special formula for premature babies.

When considering Enfamil vs Similac, you’ll probably be interested in the ingredients used. Note that there are far more non-GMO Similac formulations than there are under the Enfamil brand.


There aren’t as many pre-mixed Similac options as there are from Enfamil. While the powder range is wide-ranging, the convenience of an extensive pre-mixed selection is lacking.


The Enfamil vs Similac competition is pretty fierce. Both brands are well-regarded, with a wide range of products for all types of babies; according to dietary requirements, allergies, and age. While Enfamil offers greater convenience, Similac has a slightly more inclusive range.

Your decision will depend on which is most relevant to your baby and your personal requirements. For babies with dietary or digestive issues, it’s usually a trial-and-error process. If you’re happy with powder formulations, we’d advise giving Similac a try. For those who anticipate needing pre-mixed formulas as part of their feeding regime, Enfamil is the best option.

This article was contributed by Amanda Robertson, a mother and a clinical nutritionist from Baltimore, MD